African health sciences
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African health sciences · Jun 2020
Non infective bullous lesions: a diagnostic challenge in a minimally equipped centre- based solely on microscopic findings.
Vesicobullous lesions of skin may occur in different forms of dermatosis, which include various inflammatory, infective, autoimmune, drug induced as well as genetic conditions. Autoimmune bullous lesions, may be fatal if not treated with appropriate agents. Bearing in mind, the morbidity of these diseases, it is important to establish a firm diagnosis. ⋯ Further subtyping was done based on additional histopathological features and clinical correlation. All the patients responded appropriately to the treatment and the results correlated well with the immunofluorescence done in a few cases. This study lays emphasis upon the histopathology and clinical features keeping in consideration of the lack of ancillary techniques in many centres especially in the developing world.
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African health sciences · Jun 2020
Bio fabrication of gold nanoparticles and their combination with chemotherapy and ultrasound for effective treatment of tumors.
Chemotherapy is one of the important medical option for the cancer therapy, but still new combination of therapeutic treatment methods are needed to achieve efficient anti tumor activity. In this work, Pueraria lobata leaf extract was utilized as a bio reductant for the fabrication of the Gold nanoparticles (Au-NPs) by an ecological approach without using any harmful chemical. This work also evaluates whether the combined effect of chemotherapy along with Au-NPs and Ultrasound (US) is effective over the tumors or not. ⋯ In conclusion, Pueraria lobata leaf extract mediated synthesis of Au-NPs by an eco-friendly approach was reported in this work. The plant biomolecules of the extract were involved in the reduction and capping of the Au-NPs formed. The major conclusion is that addition of Au-NPs with chemotherapy and ultrasound has shown more effective anti-tumor activity.
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African health sciences · Jun 2020
Comparative StudyAnalysis of clinical and virologic features in Hepatitis B e Antigen (HbeAg)-negative and HbeAg-positive Egyptian chronic hepatitis B patients.
HBeAg-negative chronic hepatitis B infection has a divergent clinical course from that of HBeAg-positive infection. ⋯ HBeAg-negative patients compared with HBeAg-positive patients had older age, lower ALT and serum HBVDNA levels, but more incidence of HCC.
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African health sciences · Jun 2020
Socio-economic status and hunger among orphans and vulnerable children households in Lagos State, Nigeria.
HIV/AIDS has contributed to increasing orphans and vulnerable children in Nigeria. A measure of vulnerability is household hunger. ⋯ OVC households experienced severe hunger. Household economic strengthening would be useful strategy to mitigate the nutrition challenges of OVC in Lagos state.