African health sciences
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African health sciences · Sep 2022
The association between blood, urine, respiratory, neurobehavioral parameters and occupational exposure to organophosphorus pesticides: a cross-sectional study among formulators.
Organophosphate (OP) pesticides are one of the most extensively used chemical compounds all over the world. ⋯ In this study, the expected adverse health effects due to exposure to OP pesticides were not observed among the formulators; however, the risk of developing respiratory dysfunction was found to be more considerable among smoker subjects than the non-smoker ones. Further investigations are required to determine whether formulators' occupational exposures to OP pesticides result in certain adverse health effects.
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African health sciences · Sep 2022
Indirect serum biomarkers perform sub optimally in screening for significant liver fibrosis among HIV-infected and uninfected adults in Uganda.
Indirect serum bio-markers present an acceptable noninvasive and cheap alternative for screening of significant liver fibrosis (SLF). Evaluation of their use in resource limited settings is important to determine their utility. ⋯ Despite APRI and FIB-4 being more likely to identify participants with SLF, the overall diagnostic value of all serum bio-markers was poor with and without stratification by HIV status. We recommend the use of Fibroscan® technology as more accurate non-invasive diagnostic method for screening of SLF.
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African health sciences · Sep 2022
Case ReportsSpontaneous intrapleural rupture of mediastinal teratoma in child.
Mediastinal teratomas are rare in children. Nevertheless, they represent the most frequent mediastinal germ cell tumor. Most often, they are discovered incidentally in older children or adolescents on chest X-ray. There are other signs of discovery but less frequent: chest pain, hemoptysis and signs of mediastinal compression. Rupture into pleural space, pericardium or tracheobronchial tree are exceptional. ⋯ Intrapleural rupture is a rare complication of mature teratoma. Calcifications on chest imaging in afebrile children with pleural effusion should be suspected of mediastinal teratoma.
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African health sciences · Sep 2022
Case ReportsAssociation of ATM, CDH1 and TP53 genes polymorphisms with familial breast cancer in patients of Khyber Pakhtunkhwa, Pakistan.
Genetic studies play a significant role in understanding the underlying risk factors of breast cancer. Polymorphism in the tumor suppressor gene TP 53, CDH1 and ATM genes are found to increase susceptibility for breast cancer globally. ⋯ The present study demonstrates that CDH1rs3743674 polymorphism is associated with elevated breast cancer risk in the Pashtun ethic population of Khyber Pakhtunkhwa.
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African health sciences · Sep 2022
Factors associated with death among hospitalized COVID-19 patients in Lagos State, Nigeria: a retrospective cross-sectional study.
Lagos State has the highest burden of COVID-19 in Nigeria. We assessed associated factors with death from COVID-19 among hospitalized patients in Lagos, Nigeria. ⋯ The odds of dying was higher among males, the elderly, patients with comorbidity and severe COVID-19.