African health sciences
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African health sciences · Dec 2023
A plausible hypothesis for the higher Covid-19 mortality in Brazil.
Brazil has high Covid-19 mortality rates, especially among those patients who are intubated. It is hypothetically considered that these rates may be related to the abusive use of medicines by the population. These drugs without scientific evidence are indicated by President Bolsonaro and his supporters but are also prescribed by doctors who follow this line. The text draws attention to the risks of this phenomenon.
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African health sciences · Dec 2023
The immune-modulatory role of MSCs exerted by PI3K/AKT signaling pathway in kidney tissue after cyclophosphamide.
Cyclophosphamide (CP) is one of the most effective immunosuppressive agents. To understand the mechanisms used by the CP and MSCs in the kidney, we investigated their effects on some pathways. ⋯ MSCs play a vital function in the immune inhibition in CP-treated rats through PI3K/AKT pathway.