African health sciences
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African health sciences · Jun 2023
Mir-21 and Mir-125b as theranostic biomarkers for epithelial ovarian cancer in Tunisian women.
Ovarian cancer (OC) is the third most common cancer in women and the leading cause of death associated with gynecologic tumors. Because this disease is asymptomatic in the early stages, most patients are not diagnosed until the late stages. This highlights the need for the development of diagnostic biomarkers. MicroRNAs (miRNAs), small non-coding RNAs, are currently being explored as potential biomarkers for the early detection of various malignancies in humans. However, their expression and diagnostic value in OC have not been well studied. ⋯ Our data suggest that miR-21 and miR-125b in plasma may serve as potential circulating biomarkers for the early detection of EOC. MiR-125b may also be useful for predicting chemosensitivity in EOC patients.
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African health sciences · Jun 2023
Clinical roles of autophagy-related proteins Beclin-1 and mTOR in smoking and non-smoking patients with oral leukoplakia.
To study the expressions of autophagy-related proteins Beclin-1 and mammalian target of rapamycin (mTOR) in smoking and non-smoking patients with oral leukoplakia (OLK). ⋯ Autophagy-related proteins Beclin-1 and mTOR may be involved in the smoking-induced pathogenesis of OLK.
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African health sciences · Jun 2023
Diagnostic and prognostic value of c-MYC gene expression in hematological malignancies.
c-MYC plays vital role in regulation of cell proliferation and has been associated with tumorigenesis. This study is aimed at assessing diagnostic and prognostic value of plasma c-MYC expression to aid in early diagnosis and prognosis of hematological malignancies. ⋯ Plasma c-MYC ratio showed promising screening/diagnostic value for hematological malignancies.
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African health sciences · Jun 2023
Impact of maternal demographics on knowledge of exclusive breastfeeding among nursing mothers in Ifelodun local government, Nigeria.
Breastfeeding remains the recommended feeding plan for infants however; several factors seem to affect its knowledge and practice. ⋯ Nursing mothers in Ifelodun Local Government Area, have knowledge of exclusive breast feeding especially those who are older, literate, Christian; and multi-parous. Maternal demographics should be considered when educating nursing mothers on exclusive breastfeeding.
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African health sciences · Jun 2023
Experiences of female clients in the assisted reproductive technology process in Nigeria.
Though assisted reproductive technology (ART) has been a source of hope for many infertile couples, it is known to be associated with physical, social, psychological, and ethical challenges in different settings. ⋯ Cost of ART remain unaffordable to most Nigerians hence the need for government subsidization and in-corporation of ART services into the National Health Insurance Scheme. Additionally, lack of adequate information disclosure, shared decision-making and gendered suffering are areas of great concern among the study participants. A national regulatory guideline will ensure uniform international standard of care.