African health sciences
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African health sciences · Jun 2023
Interferon in the treatment of ill adults with Covid-19 in the Republic of Guinea.
Effective and safe antiviral treatments are required to refrain the COVID-19. ⋯ The interferon resulted effective and safe in contributing to the viral replication conversion to negative results in shorter time and to survival.
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African health sciences · Jun 2023
Predictive value of platelet-related parameters combined with pneumonia severity index score for mortality rate of patients with severe pneumonia.
To analyse the predictive value of platelet-related parameters combined with pneumonia severity index (PSI) score for the mortality rate of patients with severe pneumonia. ⋯ PLT, PDW, MPV and P-LCR are significantly abnormal in patients with severe pneumonia, and the combination of platelet-related parameters with PSI score has the highest predictive value for 28-day mortality.
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African health sciences · Jun 2023
Mir-21 and Mir-125b as theranostic biomarkers for epithelial ovarian cancer in Tunisian women.
Ovarian cancer (OC) is the third most common cancer in women and the leading cause of death associated with gynecologic tumors. Because this disease is asymptomatic in the early stages, most patients are not diagnosed until the late stages. This highlights the need for the development of diagnostic biomarkers. MicroRNAs (miRNAs), small non-coding RNAs, are currently being explored as potential biomarkers for the early detection of various malignancies in humans. However, their expression and diagnostic value in OC have not been well studied. ⋯ Our data suggest that miR-21 and miR-125b in plasma may serve as potential circulating biomarkers for the early detection of EOC. MiR-125b may also be useful for predicting chemosensitivity in EOC patients.
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African health sciences · Jun 2023
Prevalence, severity, and correlates of erectile dysfunction among male adult patients of a primary care clinic in North-West Nigeria.
Erectile dysfunction (ED) is a common sexual problem that profoundly affects intimate relationships. It is poorly studied in North-western Nigeria. ⋯ ED prevalence was high, although mainly of the mild form. Age (≥50years) and overweight/obesity predicted ED. Hence, the need for early screening, objective grading of ED, identification of modifiable risk factors (e.g., overweight/obesity) and commencing proper treatment and prevention in this setting.
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African health sciences · Jun 2023
Expression of miR-152 in cervical cancer and its influence on cisplatin resistance.
Cervical cancer has a high mortality rate. ⋯ MiR-152 suppresses the proliferation, migration and infiltration of cervical cancer cells and reduces their resistance to DDP chemotherapy by inhibiting the expressions of proteins in the ERBB3/Akt/c-myc and ERBB3/Akt/Snail pathways.