African health sciences
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African health sciences · Sep 2022
Closing the gaps in defining and conceptualising acceptability of healthcare: a qualitative thematic content analysis.
Despite the importance of healthcare acceptability, the public health community has yet to agree on its explicit definition and conceptual framework. We explored different definitions and conceptual frameworks of healthcare acceptability, and identified commonalities in order to develop an integrated definition and conceptual framework of healthcare acceptability. ⋯ We presented and described a workable definition and framework of healthcare acceptability that can be applied to different actors including patients, healthcare providers, researchers, managers or policy makers.
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African health sciences · Sep 2022
Role of hypoxia inducible factor 1α/Bcl-2/adenovirus E1B 19-kDa interacting protein 3 in alleviating effect of interleukin-4 on cerebral ischemia reperfusion injury in mice.
Cerebral ischemia reperfusion injury (CIRI) is the pathophysiological basis of various cerebrovascular diseases. The aim of this study was to explore the role of HIF-1α/BNIP3 in the alleviating effect of IL-4 on CIRI in mice. ⋯ IL-4 reduces apoptosis and oxidative stress through activating the HIF-1α/BNIP3 pathway, thereby alleviating mouse CIRI.
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African health sciences · Sep 2022
Histopathological pattern of Orbito-Ocular Lesions, a retrospective hospital-based study spanning 15 years.
Many previous studies on orbito-ocular lesions are skewed in favour of the neoplastic lesions in general and the malignant lesions in particular. This, therefore, creates a vacuum on the spectrum of these lesions, thus may result in problematic diagnostic bias by the ophthalmologist and pathologist. ⋯ This study noted a wide array of orbito-ocular lesions for which biopsies were done for histopathological diagnosis. This we hope will in no small measure increase the diagnostic precision of the ophthalmologist and the pathologists in our own environment.
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African health sciences · Sep 2022
Effect of atrial septal dilation tumor and patent foramen rotundus on cryptogenic ischemic stroke in young and middle-aged patients.
To investigate the effect of atrial septal aneurysm (ASA) and patent foramen ovale (PFO) on cryptogenic ischemic stroke in young and middle-aged patients. ⋯ Atrial septal aneurysm combined with PFO and PFO are independent influencing factors factor for the occurrence of cryptogenic ischemic stroke in young and middle-aged people, which is worthy of further study.
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African health sciences · Sep 2022
Meta AnalysisAssociation of the IL-4R Q576R Polymorphism with Pediatric Asthma: a meta-analysis.
The relationship between Q576R polymorphism of IL-4 receptor (IL-4R) gene and pediatric asthma risk is still undefined. To this end, this meta-analysis was performed to explore the above controversy. ⋯ Our findings suggested that G allele of IL-4R Q576R polymorphism is associated with increased risk of pediatric asthma. Anyhow, delicately-designed, large-scale studies should be conducted to further confirm the current outcomes.