IEEE transactions on bio-medical engineering
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IEEE Trans Biomed Eng · Oct 2001
Development of a time-cycled volume-controlled pressure-limited respirator and lung mechanics system for total liquid ventilation.
Total liquid ventilation can support gas exchange in animal models of lung injury. Clinical application awaits further technical improvements and performance verification. Our aim was to develop a liquid ventilator, able to deliver accurate tidal volumes, and a computerized system for measuring lung mechanics. ⋯ Improvements in gas exchange and lung mechanics were observed during liquid ventilation, without impairment of cardiovascular profiles. The total liquid ventilator maintained accurate control of tidal volumes and the sequencing of inspiration/expiration. The computerized system demonstrated its ability to monitor in vivo lung mechanics, providing valuable data for early decision making.
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IEEE Trans Biomed Eng · Oct 2001
Analysis of monophasic and biphasic electrical stimulation of nerve.
In an earlier study, biphasic and monphasic electrical stimulation of the auditory nerve was performed in cats with a cochlear implant. Single-unit recordings demonstrated that spikes resulting from monophasic and biphasic stimuli have different thresholds and latencies. ⋯ A simple analysis of a linear, "integrate to threshold" membrane model accounts for the threshold and latency differences observed experimentally and computationally. Since biphasic stimuli are used extensively in functional electrical stimulation, this analysis greatly simplifies the biophysical interpretation of responses to clinically relevant stimuli by relating them to the responses obtained with monophasic stimuli.
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IEEE Trans Biomed Eng · Oct 2001
Multichannel ECG compression using multichannel adaptive vector quantization.
Adaptive vector quantization (AVQ) is a recently proposed approach for electrocardiogram (ECG) compression. The adaptability of the approach can be used to control the quality of reconstructed signals. However, like most of other ECG compression methods, AVQ only deals with the single-channel ECG, and for the multichannel (MC) ECG, coding ECG signals on a channel by channel basis is not efficient, because the correlation across channels is not exploited. ⋯ The experimental results show that, for exactly the same quality of reconstructed signals, the MC-AVQ performs better than single-channel AVQ in terms of bit rate. A theoretical analysis supporting this result is also demonstrated in this paper. For the same and relatively good visual quality, the average compressed data rate/channel is reduced from 293.5 b/s using the single-channel AVQ to 238.2 b/s using the MC-AVQ in the MIT/BIH case.