IEEE transactions on bio-medical engineering
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IEEE Trans Biomed Eng · May 2011
Depth of anesthesia during multidrug infusion: separating the effects of propofol and remifentanil using the spectral features of EEG.
General anesthesia is usually induced with a combination of drugs. In addition to the hypnotic agent, such as propofol, opioids are often used due to their synergistic hypnotic and analgesic properties. ⋯ By applying a floating search method, a well-performing feature set is achieved to estimate the effects of propofol during induction of anesthesia and to classify whether or not remifentanil has been coadministered. It is shown that including the detection of the presence of opioids to the estimated effect of propofol significantly improves the determination of the clinical state of the patient, i.e., if the patient will respond to a painful stimulation.