Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

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• Clin. Gastroenterol. Hepatol. · Aug 2004

  Randomized Controlled Trial Clinical Trial

  Effect of alosetron on bowel urgency and global symptoms in women with severe, diarrhea-predominant irritable bowel syndrome: analysis of two controlled trials.

  The aim of this study was to assess the effect of alosetron on bowel urgency and irritable bowel syndrome (IBS) global improvement in diarrhea-predominant IBS (D-IBS). ⋯ Alosetron effectively manages bowel urgency and improves global symptoms in women with severe chronic D-IBS.

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• Clin. Gastroenterol. Hepatol. · Aug 2004

  Review Comparative Study

  Effectiveness of proton pump inhibitors in nonerosive reflux disease.

  Little information is available about the efficacy of proton pump inhibitors (PPIs) in patients with nonerosive reflux disease (NERD). We aimed to synthesize available data and determine the effectiveness of PPIs on symptom resolution in patients with NERD. ⋯ PPIs provide a more modest therapeutic gain in patients with NERD as compared with those with EE. A trend in increased therapeutic gain for NERD patients was shown throughout the 4 weeks, suggesting that 4 weeks of follow-up evaluation may be insufficient to show full therapeutic gain in this patient population.

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