European urology focus
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European urology focus · Nov 2020
ReviewNocebo Response in the Pharmacological Management of Overactive Bladder: A Systematic Review and Meta-analysis.
The role of a nocebo response in managing urology patients is unclear. ⋯ In this meta-analysis of 57 studies comprising 15 446 patients, we reviewed the adverse events extracted from the placebo arms of randomized controlled trials studying therapies for overactive bladder. Dry mouth, constipation, headache, and urinary tract infection were the most common adverse events. Adverse events varied based on the drug type and the route of administration. Negative expectations from the therapy and giving verbal information to the patient can cause/alleviate adverse events.