Liver international : official journal of the International Association for the Study of the Liver
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Through a genome-wide association study of a Japanese population, we recently identified TNFSF15, a gene encoding TNF-like ligand 1A (TL1A), as a susceptibility gene for primary biliary cirrhosis (PBC). We investigated the clinical significance of TL1A and one of its receptors, decoy receptor 3 (DcR3), in PBC. ⋯ These results indicate that TL1A and DcR3 may play an important role in the pathogenesis of PBC.