Journal of the National Comprehensive Cancer Network : JNCCN
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J Natl Compr Canc Netw · May 2005
ReviewGenomics-based prognosis and therapeutic prediction in breast cancer.
Breast cancer is a heterogeneous disease. DNA microarray technology is being applied to breast cancer to identify new prognostic biomarkers, to predict response to therapy, and to discover targets for the development of novel therapies. ⋯ We note that factors that predict metastatic disease are not necessarily the same factors that predict therapeutic response. We believe that the characterization and discernment of different systems among breast cancers is crucial for understanding drug sensitivity and resistance mechanisms and for guiding therapy.