Journal of the National Comprehensive Cancer Network : JNCCN
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J Natl Compr Canc Netw · Apr 2015
Delayed recovery and increased severity of Paclitaxel-induced peripheral neuropathy in patients with diabetes.
Although diabetes mellitus (DM) is recognized as a risk factor for chemotherapy-induced neurotoxicity, its true impact on intensity and time course of peripheral neuropathy is still unclear. The goal was to analyze the relevance of preexisting DM to weekly paclitaxel-induced peripheral neuropathy (PIPN). ⋯ Significantly more dose delays and reductions because of PIPN occurred in patients with DM. Preexisting DM associates with long-lasting significant PIPN in patients treated with wP. Benefits and risks of long-term significant PIPN should be carefully balanced in patients with DM before starting wP chemotherapy.