Expert opinion on drug safety
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Expert Opin Drug Saf · May 2010
Review Comparative StudyHeadache and medication overuse: are clinical case series appropriate to reveal differential risks of different medications?
The question of whether different migraine and headache medications show a differential risk of medication overuse headache (MOH) induction has been discussed extensively but has not been definitively answered to date. ⋯ Despite several different attempts to obtain direct or indirect answers from clinical case series, the fact is that due to the intrinsic selection bias, confounding and other limitations inherent to clinical case series, they are not suitable to answer this question reliably. Thus, the repeated claims of a differential risk of different drugs and drug groups are simply not scientifically sound.