Revista da Associacao Medica Brasileira (1992)
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Rev Assoc Med Bras (1992) · Apr 2020
miR-125a-5p inhibits cancer stem cells phenotype and epithelial to mesenchymal transition in glioblastoma.
Glioblastoma (GBM) is a common type of cancer with high mortality. Epithelial to mesenchymal transition (EMT) plays a vital role in the development of glioblastoma. The aim of this study is to evaluate the role of miR-125a-5p in glioblastoma and in the tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma. ⋯ We concluded that miR-125a-5p is one of the key microRNAs regulating CSCs and EMT programs in glioblastoma. The results suggested that miR-125a-5p might be a novel therapy target for glioblastoma.
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Rev Assoc Med Bras (1992) · Apr 2020
Association between atherogenic dyslipidemia and fournier's gangrene.
We aimed to determine whether atherogenic dyslipidemia is associated with the disease and morbidity in our patients treated for Fournier's gangrene (FG). ⋯ Our study has demonstrated that atherogenic dyslipidemia, especially hypertriglyceridemia, is an important factor affecting morbidity and associated with high patient care costs after hospitalization and discharge in FG.
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Rev Assoc Med Bras (1992) · Apr 2020
Retro-odontoid pseudotumor: a poorly recognized alteration of the craniocervical junction.
Retro-odontoid pseudotumor (ROP) is a rare disease that affects the atlantoaxial joint and, in general, is associated with local biomechanical alterations that may or may not cause instability. ⋯ The ROP is still poorly recognized as a differential diagnosis between the diseases of the cranial-cervical junction. The information available in the literature analyzed was based mainly on the study of reports or case series; therefore, it is insufficient to define conducts with a high level of scientific evidence.