Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Mar 2010
Randomized Controlled Trial Multicenter StudyCan oral vitamin K before elective surgery substitute for preoperative heparin bridging in patients on vitamin K antagonists?
After a vitamin K antagonist (VKA) overdose, 1-2 mg of oral vitamin K can lower the International Normalized Ratio (INR) to the therapeutic range. ⋯ Oral vitamin K (1 mg) cannot substitute for heparin bridging before surgery. In addition, one-third of patients on VKAs were exposed to a risk of bleeding (overdose) or thrombosis (underdose), thus highlighting the need for new oral anticoagulants.