Journal of thrombosis and haemostasis : JTH
-
J. Thromb. Haemost. · Nov 2013
Multicenter StudyVariable D-dimer thresholds for diagnosis of clinically suspected acute pulmonary embolism.
Computed tomography pulmonary angiography (CTPA) is frequently requested using diagnostic algorithms for suspected pulmonary embolism (PE). For suspected deep vein thrombosis, it was recently shown that doubling the D-dimer threshold in patients with low pretest probability safely decreased the number of ultrasonograms. We evaluated the safety and efficiency of a similar strategy in patients with suspected PE. ⋯ Applying selective D-dimer thresholds reduces the need for CTPA by 11 percentage points but is associated with an increased failure rate. Prospective studies should evaluate the safety and net clinical benefit of this approach.
-
J. Thromb. Haemost. · Nov 2013
GFI1B mutation causes a bleeding disorder with abnormal platelet function.
GFI1B is a transcription factor important for erythropoiesis and megakaryocyte development but previously unknown to be associated with human disease. ⋯ GFI1B mutation represents a novel human bleeding disorder, and the described phenotype identifies GFI1B as a critical regulator of platelet shape, number, and function.