Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Jul 2013
Review Meta AnalysisImpact of double-blind vs. open study design on the observed treatment effects of new oral anticoagulants in atrial fibrillation: a meta-analysis.
The prospective, randomized, open, blinded endpoint evaluation (PROBE) design has been proposed as a valid alternative to the double-blind (DB) design for trials comparing new oral anticoagulants (NOAs) with INR-adjusted vitamin K antagonists in patients with non-valvular atrial fibrillation (NVAF). ⋯ Our meta-analysis showed no significant interaction of study design for the main efficacy and safety outcomes. However, the non-significantly exaggerated reduction in SSE suggests interdependence of treatment effect and PROBE design, especially for hemorrhagic stroke.
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J. Thromb. Haemost. · Jul 2013
Randomized Controlled Trial Multicenter StudyA randomized controlled trial of fresh frozen plasma for treating venom-induced consumption coagulopathy in cases of Australian snakebite (ASP-18).
Venom-induced consumption coagulopathy (VICC) is a major effect of snake envenoming. ⋯ FFP administration after antivenom administration results in more rapid restoration of clotting function in most patients, but no decrease in discharge time. Early FFP administration (< 6-8 h) post-bite is less likely to be effective.
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J. Thromb. Haemost. · Jul 2013
Incidence of venous thromboembolism after elective knee arthroscopic surgery: a historical cohort study.
The incidence of symptomatic venous thromboembolism (VTE) after knee arthroscopy is uncertain. ⋯ The incidence of symptomatic VTE after arthroscopic knee surgery is very low. Older age and hospitalization are associated with increased risk. Routine prophylaxis to prevent symptomatic VTE is likely not needed in this patient population.
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J. Thromb. Haemost. · Jul 2013
Platelet shedding of CD40L is regulated by matrix metalloproteinase-9 in abdominal sepsis.
Platelet-derived CD40L is known to regulate neutrophil recruitment and lung damage in sepsis. However, the mechanism regulating shedding of CD40L from activated platelets is not known. We hypothesized that matrix metalloproteinase (MMP)-9 might cleave surface-expressed CD40L and regulate pulmonary accumulation of neutrophils in sepsis. ⋯ Our novel data propose a role of MMP-9 in regulating platelet-dependent infiltration of neutrophils and tissue damage in septic lung injury by controlling CD40L shedding from platelets. We conclude that targeting MMP-9 may be a useful strategy to limit acute lung injury in abdominal sepsis.