Journal of thrombosis and haemostasis : JTH
-
J. Thromb. Haemost. · Feb 2015
Multicenter StudyCardiac troponin-I on diagnosis predicts early death and refractoriness in acquired thrombotic thrombocytopenic purpura. Experience of the French Thrombotic Microangiopathies Reference Center.
Cardiac involvement is a major cause of mortality in patients with thrombotic thrombocytopenic purpura (TTP). However, diagnosis remains underestimated and delayed, owing to subclinical injuries. Cardiac troponin-I measurement (cTnI) on admission could improve the early diagnosis of cardiac involvement and have prognostic value. ⋯ A CTnI level of > 0.25 μg L(-1) at presentation in patients with TTP appears to be an independent factor associated with a three-fold increase in the risk of death or refractoriness. Therefore, cTnI level should be considered as a prognostic indicator in patients diagnosed with TTP.
-
J. Thromb. Haemost. · Feb 2015
Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factors.
Family history of venous thromboembolism (VTE) has been suggested to be more useful in risk assessment than thrombophilia testing. ⋯ Prediction of VTE in high-risk individuals was more accurate when a combination of clinical and genetic predictors with SNP-SNP interactions was included in a risk score.