Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Apr 2015
Review Meta AnalysisRecombinant human soluble thrombomodulin in severe sepsis: a systematic review and meta-analysis.
Although recombinant human soluble thrombomodulin (rhTM) is a widely used novel anticoagulant agent for disseminated intravascular coagulation (DIC) in Japan, its clinical efficacy in sepsis-induced DIC has not been demonstrated convincingly. ⋯ The rhTM was associated with a trend in reduction of mortality at 28-30 days in sepsis-induced DIC patients. Further large rigorous trials are needed to confirm or refute these findings before implications for practice are clear.