Journal of thrombosis and haemostasis : JTH
-
J. Thromb. Haemost. · Mar 2017
Randomized Controlled Trial Multicenter StudySafety and efficacy of BAY 94-9027, a prolonged-half-life factor VIII.
Essentials Recombinant factor VIII BAY 94-9027 conjugates in a site-specific manner with polyethylene glycol. BAY 94-9027 was given to patients with severe hemophilia A as prophylaxis and to treat bleeds. BAY 94-9027 prevented bleeds at dose intervals up to every 7 days and effectively treated bleeds. ⋯ Six hundred and thirty-six of 702 bleeds (90.6%) were controlled with ≤ 2 infusions. No patient developed a FVIII inhibitor. Conclusions BAY 94-9027 prevented bleeding across three individually tailored dose regimens and was effective for treatment of bleeds.
-
J. Thromb. Haemost. · Mar 2017
Multicenter Study Observational StudyBleeding risk of terminally ill patients hospitalized in palliative care units: the RHESO study.
Essentials Bleeding incidence as hemorrhagic risk factors are unknown in palliative care inpatients. We conducted a multicenter observational study (22 Palliative Care Units, 1199 patients). At three months, the cumulative incidence of clinically relevant bleeding was 9.8%. Cancer, recent bleeding, thromboprophylaxis and antiplatelet therapy were independent risk factors.