Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Feb 2018
Meta AnalysisClinical prediction rules for mortality in patients with pulmonary embolism and cancer to guide outpatient management: a meta-analysis.
Essentials Clinical prediction rules (CPRs) can stratify patients with pulmonary embolism (PE) and cancer. A meta-analysis was done to assess prognostic accuracy in CPRs for mortality in these patients. Eight studies evaluating ten CPRs were included in this study. CPRs should continue to be used with other patient factors for mortality risk stratification.
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J. Thromb. Haemost. · Feb 2018
Hemodynamic force triggers rapid NETosis within sterile thrombotic occlusions.
Essentials Neutrophil extracellular traps (NETs) are generated during thrombosis and sepsis. The effect of hemodynamics on NETosis during sterile thrombosis was studied using microfluidics. Pressure gradients > 70 mmHg per mm-clot across sterile occlusions drive shear-induced NETosis. High interstitial hemodynamic forces trigger rapid NET release.