Journal of thrombosis and haemostasis : JTH
-
J. Thromb. Haemost. · Dec 2019
Randomized Controlled Trial Multicenter Study Comparative StudyRandomized phase 2 trial comparing JNJ-9375, a thrombin-directed antibody, with apixaban for prevention of venous thrombosis.
JNJ-9375 is an antibody against exosite 1 on thrombin, inhibits substrate binding but not catalytic activity. ⋯ JNJ-9375 was safe but less effective than apixaban. This may reflect weak thrombin inhibition or inability of JNJ-9375 to attenuate the growth of thrombi that formed before drug administration.