Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Aug 2013
Retinal vein and artery occlusions: a risk factor for stroke in atrial fibrillation.
Retinal vascular occlusions may constitute an independent risk factor for stroke in patients with atrial fibrillation. ⋯ A history of retinal arterial or retinal venous occlusion is associated with an increased risk of stroke/TE/TIA in patients with atrial fibrillation. Thus, prior retinal vascular occlusion may be considered as a previous thromboembolic event when evaluating stroke risk in patients with atrial fibrillation.
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J. Thromb. Haemost. · Jul 2013
Review Meta AnalysisImpact of double-blind vs. open study design on the observed treatment effects of new oral anticoagulants in atrial fibrillation: a meta-analysis.
The prospective, randomized, open, blinded endpoint evaluation (PROBE) design has been proposed as a valid alternative to the double-blind (DB) design for trials comparing new oral anticoagulants (NOAs) with INR-adjusted vitamin K antagonists in patients with non-valvular atrial fibrillation (NVAF). ⋯ Our meta-analysis showed no significant interaction of study design for the main efficacy and safety outcomes. However, the non-significantly exaggerated reduction in SSE suggests interdependence of treatment effect and PROBE design, especially for hemorrhagic stroke.
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J. Thromb. Haemost. · Jul 2013
Randomized Controlled Trial Multicenter StudyA randomized controlled trial of fresh frozen plasma for treating venom-induced consumption coagulopathy in cases of Australian snakebite (ASP-18).
Venom-induced consumption coagulopathy (VICC) is a major effect of snake envenoming. ⋯ FFP administration after antivenom administration results in more rapid restoration of clotting function in most patients, but no decrease in discharge time. Early FFP administration (< 6-8 h) post-bite is less likely to be effective.