JAMA network open
The most recent articles from:
JAMA Netw Open
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Comparative Study Historical Article
Comparison of Estimated Excess Deaths in New York City During the COVID-19 and 1918 Influenza Pandemics.
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Interpreting randomized clinical trials (RCTs) and their clinical relevance is challenging when P values are either marginally above or below the P = .05 threshold. ⋯ This cross-sectional study found that a relatively small number of events (median of 8) had to change to move the primary end point of an RCT from nonsignificant to statistically significant. These findings emphasize the nuance required when interpreting trial results that did not meet prespecified significance thresholds.