Chinese medical journal
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Chinese medical journal · Feb 2025
Transcription factor ATF3 aggravates kidney fibrosis by maintaining the state of histone H3 lysine 27 acetylation.
Chronic kidney disease (CKD) is a global health issue, with renal fibrosis being a common pathway in CKD development. Histone modification plays crucial roles in transcriptional regulation, but their pathological functions and mechanisms in CKD are not well understood. ⋯ ATF3 promotes kidney injury and fibrosis in CKD by maintaining the state of H3k27ac via recruiting HATs network.
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Chinese medical journal · Feb 2025
Machine learning-based unsupervised phenotypic clustering analysis of patients with IgA nephropathy: Distinct therapeutic responses of different groups.
Immunoglobulin A nephropathy (IgAN) has a heterogeneous clinical presentation. Comparison of different IgAN subgroups may facilitate the application of more targeted therapies. This study was aimed to distinct disease phenotypes in IgAN and to develop prognostic models for renal composite outcomes. ⋯ The unsupervised clustering method provided reliable classification of IgAN patients into different subgroups according to clinical features, prognoses, and treatment responsiveness. Our subgroup-based prediction model has significant clinical utility for the assessment of risk and treatment in patients with IgAN.