Chinese medical journal
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Chinese medical journal · Jul 2018
Case ReportsA Novel Mutation of Mitochondrial T14709C Causes Myoclonic Epilepsy with Ragged Red Fibers Syndrome in a Chinese Patient.
Myoclonic epilepsy with ragged red fibers (MERRF) syndrome is characterized by myoclonus, generalized epilepsy, cerebellar ataxia, and ragged red fibers (RRFs) in the muscle. T-to-C transition at nucleotide position 14709 in the mitochondrial tRNA glutamic acid (tRNAGlu) gene has previously been associated with maternally inherited diabetes and deafness. However, the association between MERRF and mitochondrial T14709C mutation (m.T14709C) has never been reported before. ⋯ We present a sporadic patient with typical MERRF presentation carrying the mutation of m.T14709C, which expanded the spectrum of m.T14709C.
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Chinese medical journal · Jul 2018
Genistein Improves Liver Damage in Male Mice Exposed to Morphine.
Morphine is commonly used to treat severe pain. This substance is significantly metabolized in the liver and causes disturbing effects. Genistein is an isoflavone and has antioxidant properties. The aim of this study was to evaluate the effects of genistein against morphine damages on mouse liver. ⋯ It seems that genistein administration might improve liver damages induced by morphine in mice.
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Chinese medical journal · Jul 2018
Potential Clinical Risk of Inflammation and Toxicity from Rare-Earth Nanoparticles in Mice.
Nanotechnology is emerging as a promising tool to perform noninvasive therapy and optical imaging. However, nanomedicine may pose a potential risk of toxicity during in vivo applications. In this study, we aimed to investigate the potential toxicity of rare-earth nanoparticles (RENPs) using mice as models. ⋯ The use of bare RENPs may cause possible hepatotoxicity and nephritictoxicity in mice.