Clinical medicine & research
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Multicenter Study Clinical Trial
Innate immunity SNPs are associated with risk for severe sepsis after burn injury.
To analyze allelic association with clinical outcome in a cohort of burn patients. ⋯ Carriage of variant alleles at immune response genes were associated with increased risk for severe sepsis after burn injury.
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Comparative Study Clinical Trial
Comparison of an in-house and a commercial RD1-based ELISPOT-IFN-gamma assay for the diagnosis of Mycobacterium tuberculosis infection.
To compare a RD1-based in-house ELISPOT-interferon-gamma (IFN-gamma) assay with a commercial (T-SPOT.TB) assay for the diagnosis of Mycobacterium tuberculosis (TB) infection and the efficacy of the tuberculin skin test (TST) and ELISPOT assay in detecting latent TB infection (LTBI). ⋯ Our in-house ELISPOT assay based on a restricted pool of highly selected peptides is equivalent to the commercial T-SPOT.TB assay, is cheaper and is probably not confounded, unlike the TST, by BCG vaccination in our setting.