Journal of the American Pharmacists Association : JAPhA
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J Am Pharm Assoc (2003) · Sep 2004
Variability in tablet fragment weights when splitting unscored cyclobenzaprine 10 mg tablets.
To determine the weight variation and calculated dosing variability of tablet fragments upon splitting unscored cyclobenzaprine hydrochloride 10 mg tablets using two common tablet splitting devices. ⋯ Tablet fragments obtained after splitting this generic cyclobenzaprine 10 mg product varied considerably in weight and estimated drug content. Accordingly, splitting cyclobenzaprine 10 mg tablets to achieve 5 mg doses could result in unpredictable dosing and therapeutic response.