Expert review of anti-infective therapy
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Expert Rev Anti Infect Ther · Jul 2021
ReviewThe immunology of SARS-CoV-2 infection, the potential antibody based treatments and vaccination strategies.
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a potentially fatal agent for a new emerging viral disease (COVID-19) is of great global public health emergency. Herein, we represented potential antibody-based treatments especially monoclonal antibodies (mAbs) that may exert a potential role in treatment as well as developing vaccination strategies against COVID-19. Areas covered: We used PubMed, Google Scholar, and clinicaltrials.gov search strategies for relevant papers. ⋯ Although there has not been any approved specific vaccine until now, developing vaccination strategies may have a protective effect against COVID-19. Expert opinion: An antiviral mAbs could be a safe and high-quality therapeutic intervention which is greatly recommended for COVID-19. Additionally, the high sequence homology between the SARS-CoV-2 and SARS/MERS viruses could shed light on developing to design a vaccine against SARS-CoV-2.