European heart journal. Cardiovascular pharmacotherapy
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Eur Heart J Cardiovasc Pharmacother · Jan 2018
ReviewInterleukin-1 blockade for the treatment of pericarditis.
Pericarditis is a debilitating condition that results from profound inflammation of the pericardial tissue. Between 10 and 15% of first episodes of acute pericarditis will be followed by several episodes refractory to conventional treatment. ⋯ Interruption of the IL-1 circuit has been shown to have a favourable risk profile in several disease states. In this review, we discuss the growing body of evidence which supports the use of IL-1 blockade in the treatment of recurrent pericarditis as well as provide practical considerations for the use of IL-1 blockade in clinical practice.