American journal of obstetrics & gynecology MFM
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Am J Obstet Gynecol MFM · Jul 2021
Randomized Controlled Trial Multicenter StudyIntrapartum opioid analgesia and childhood neurodevelopmental outcomes among infants born preterm.
There are concerns regarding neurobehavioral changes in infants exposed to parenteral opioids during labor; however, long-term neurodevelopment remains unstudied. ⋯ Among a population of preterm infants vulnerable to neurologic impairment, intrapartum exposure to parenteral opioids was not associated with an increased risk for neurodevelopmental delay up to 2 years of age, nor did these infants have worse perinatal outcomes.