Heart rhythm : the official journal of the Heart Rhythm Society
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The electrophysiological substrate underlying atrial fibrillation (AF) progression remains difficult to identify. ⋯ Patients with AFr after first ablation exhibit IP more frequently at redo ablation than do patients with OATr. IP correlates with more advanced AFr type, larger LA volumes, and progressive right atrial enlargement. PV reconnection is not associated with AFr. Changes in post-PVI AFI may accurately indicate progression of extra-PV AF-maintaining substrate.