European neurology
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Intracranial aneurysms with daughter blebs appear to have a higher risk of rupture. Whether hemodynamic factors are involved in this phenomenon is not clear. ⋯ These observations indicate that low WSS and high OSI in the daughter blebs might be involved in increasing the risk of rupture. The localized striking force caused by inflow jets may contribute to the development of daughter blebs. However, a precise role of hemodynamics in predicting the future rupture of daughter blebs needs further study.
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The safety of intravenous (IV) thrombolysis when administered between 4.5 and 6 h after acute ischemic stroke with alteplase has not been established. ⋯ IV thrombolysis in patients who fulfill the NINDS study criteria may still be considered up to 6 h after ischemic stroke.
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We know little of the current status of stroke in Tibet Autonomous Region in China. This study was designed to investigate the characteristics of acute stroke in Tibet. ⋯ ICH is the dominant stroke subtype in Tibet Autonomous Region, and can be attributed to high rates of hypertension and heavy alcohol consumption. Greater public awareness of stroke and effective management of risk factors should be implemented immediately in Tibet.
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Review Historical Article
Possible sites of therapeutic action in restless legs syndrome: focus on dopamine and α2δ ligands.
Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by abnormal sensations that occur primarily at rest or during sleep, which are alleviated by movement of the affected limb. The pathophysiology of RLS remains unclear, although roles for dopamine dysfunction and brain iron deficiency have been proposed. ⋯ Modulation of central and peripheral neuronal circuits may also explain the potential therapeutic sites of action of opioids, adenosine receptor ligands, and voltage-gated calcium channel α(2)δ ligands in RLS. The known and possible therapeutic benefits of these agents and their relationship to dopaminergic dysfunction in RLS are discussed in this review.
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Randomized Controlled Trial Clinical Trial
Is it always necessary to apply botulinum toxin into the lower facial muscles in hemifacial spasm?: a randomized, single-blind, crossover trial.
Botulinum toxin (BTX) injections are accepted as safe and efficacious in the treatment of hemifacial spasm (HFS), but it is still debated whether BTX treatment of lower facial muscles should be performed or not. ⋯ Our data suggest that BTX application to lower facial muscles might not be necessary in patients with mild lower facial involvement.