Brazilian journal of otorhinolaryngology
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Braz J Otorhinolaryngol · May 2019
Protective effect of gallic acid against cisplatin-induced ototoxicity in rats.
Cisplatin is an antineoplastic agent widely used in the treatment of a variety of cancers. Ototoxicity is one of the main side-effects restricting the use of cisplatin. ⋯ In the light of our findings, we think that gallic acid may have played a protective role against cisplatin-induced ototoxicity in rats, as indicated by the distortion product otoacoustic emissions test results, biochemical findings and immunohistochemical analyses.