The Journal of bone and joint surgery. American volume
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J Bone Joint Surg Am · Jul 1995
Randomized Controlled Trial Clinical TrialEffect of ketorolac tromethamine on bleeding and on requirements for analgesia after total knee arthroplasty.
The effect of ketorolac tromethamine, a non-steroidal anti-inflammatory drug, on postoperative blood loss and on the requirement for morphine was assessed after total knee arthroplasty, an operation in which blood loss is mainly measured rather than estimated. The purpose of this prospective, randomized, double-blind clinical trial was to determine whether administration of ketorolac in the perioperative period would increase bleeding related to the operation. Fifty-nine patients who had a total knee arthroplasty received either thirty milligrams of ketorolac or a placebo consisting of saline solution, intravenously, every six hours, in four doses. ⋯ The patients who received ketorolac used 27 per cent less morphine than those who received the placebo (40.0 +/- 23.4 milligrams compared with 55.1 +/- 23.5 milligrams [mean and standard deviation]); this difference was significant (p < 0.05). On the first day after the operation, the hematocrit decreased from 0.364 +/- 0.043 preoperatively to 0.278 +/- 0.032 in the patients who received ketorolac and from 0.363 +/- 0.046 to 0.298 +/- 0.030 in the patients who received the placebo. The 6 per cent greater decrease in the group that received ketorolac was significant (p < 0.05) but not clinically important.(ABSTRACT TRUNCATED AT 250 WORDS)
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J Bone Joint Surg Am · Jul 1995
The value of the tip-apex distance in predicting failure of fixation of peritrochanteric fractures of the hip.
Failure of fixation of peritrochanteric fractures that have been treated with a fixed-angle sliding hip-screw device is frequently related to the position of the lag screw in the femoral head. A simple measurement has been developed to describe the position of the screw. This measurement, the tip-apex distance, is the sum of the distance from the tip of the lag screw to the apex of the femoral head on an anteroposterior radiograph and this distance on a lateral radiograph, after controlling for magnification. ⋯ Of the nineteen failures that were identified, sixteen were due to the device cutting out of the femoral head. The average tip-apex distance was twenty-four millimeters (range, nine to sixty-three millimeters) for the successfully treated fractures compared with thirty-eight millimeters (range, twenty-eight to forty-eight millimeters) for those in which the screw cut out (p = 0.0001). None of the 120 screws with a tip-apex distance of twenty-five millimeters or less cut out, but there was a very strong statistical relationship between an increasing tip-apex distance and the rate of cutout, regardless of all other variables related to the fracture.(ABSTRACT TRUNCATED AT 250 WORDS)