Acta neurochirurgica
-
Acta neurochirurgica · Jun 2004
Early effects of mild brain trauma on the cytoskeletal proteins neurofilament160 and MAP2, and the preventive effects of mexilitine.
The aims were to investigate the early effects of graded, closed, mild head injury on neurofilament protein (NF160) and microtubule-associated protein-2 (MAP2) and to examine the levels of lipid peroxidation and the impact of mexilitine, inhibitor of lipid peroxidation, pretreatment on tissue damage. ⋯ In conclusion, our results show that the cytoskeletal proteins we investigated have different capacities for resisting injury, and that MAP2 is more vulnerable to injury than NF160. One of the reason for this cytoskeletal disruption may be increased lipid peroxidation. Inhibition of lipid peroxidation by pre-treatment with 50-mg/kg mexilitine significantly reduces the level of lipid peroxidation and may protect MAP2 and NF160 integrity in closed mild head injury. This protection is inversely proportional to the magnitude of the applied force.
-
Acta neurochirurgica · Jun 2004
Selective diagnostic cervical nerve root block--correlation with clinical symptoms and MRI-pathology.
The aim of this study is to describe the method of a cervical selective diagnostic nerve root block (SNRB) technique and assess its ability to correlate clinical symptoms with MRI findings in patients with cervical radicular pain and a single level degenerative disease. ⋯ The block procedure seems relevant for revealing a relationship between radiological pathology and clinical symptoms and signs.
-
Acta neurochirurgica · Jun 2004
Review Comparative StudyIntra-operative magnetic resonance imaging in neurosurgery.
Intra-operative MRI (iMRI) has been incorporated into modern neurosurgical operating rooms as a guide for neurosurgical interventions for almost ten years. This technology has been shown to be a useful modality in brain tumour surgery and biopsy; its use in spine, vascular and epilepsy surgery has been evolving. ⋯ We evaluate currently available iMRI systems and their applications in neurosurgery. Future possibilities related to iMRI systems are mentioned in the light of current advances.
-
Acta neurochirurgica · Jun 2004
Case ReportsIs skull fracture necessary for developing an intradiploic pseudomeningocele as a complication of head injury in adulthood?
We report the case of an adult with a posttraumatic intradiploic pseudomeningocele which caused an expanded osteolytic skull lesion. Local pain and swelling, the only symptoms of the lesion, regressed after surgery. Intradiploic pseudomeningocele must be distinguished from intradiploic leptomeningeal cyst, which is of traumatic origin or arachnoid cyst and epidermoid cyst, which are of congenital origin. We also discuss the development of intradiploic pseudomeningoceleafter head trauma without skull fracture in adulthood and suggest a possible mechanism.
-
Astroblastoma is a rare glial tumour about which little is known. ⋯ Classification and histogenesis of this tumour is still debated. The lack of a clinicopathological correlation makes the prognosis of this tumour unpredictable. The optimal management is not defined, but total resection and post-operative radiotherapy seem to be the effective means to treat the astroblastoma.