Basic & clinical pharmacology & toxicology
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Basic Clin. Pharmacol. Toxicol. · Jun 2012
Randomized Controlled TrialAssessment of the analgesic effect of remifentanil using three pain models in healthy Korean volunteers: a randomized, controlled study.
Quantitative pain assessment in human beings is useful for developing new analgesics. This study assessed the analgesic effect of remifentanil in 20 healthy Korean men using three pain models to investigate whether these models can be used in Asians. The study was a double-blind, placebo-controlled, two-way cross-over study. ⋯ Remifentanil conferred a significantly higher pressure pain threshold and tolerance than placebo (p = 0.0001). There was a trend of increasing mechanical pain threshold with remifentanil, although it was not statistically significant. The results suggest that heat pain and pressure pain models are valid in East Asians for assessing analgesic effects.