Arthritis & rheumatology (Hoboken, N.J.)
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Arthritis Rheumatol · Feb 2014
Multicenter StudyGlucocorticoid dose thresholds associated with all-cause and cardiovascular mortality in rheumatoid arthritis.
To delineate daily and cumulative glucocorticoid dose thresholds associated with increased mortality rates in rheumatoid arthritis (RA). ⋯ Glucocorticoid use in RA is associated with a dose-dependent increase in mortality rates, with a daily threshold dose of 8 mg, at which the number of deaths increased in a dose-dependent manner. These findings may assist clinicians in selecting the appropriate glucocorticoid dosage for RA patients who require these agents.