Current neurovascular research
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Studies investigating cognitive impairment in stroke-free patients with carotid artery stenosis have led to inconsistent results. Furthermore, the pathophysiological mechanism leading to cognitive impairment remains unclear. Cerebral hypoperfusion and arterio-arterial microembolization are discussed. ⋯ In our selected group of patients, a higher grade of carotid artery stenosis is associated with cognitive decline. This process is independent of white matter lesion load. Possible pathophysiological implications are discussed.