Revista espanola de salud publica
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Rev Esp Salud Publica · Oct 2021
[Humoral immunity against SARS-CoV-2 in workers of social health care centers of Castilla y León after vaccination with the BNT162b2 mRNA vaccine from Pfizer/Biontech.]
Workers and residents of care facilities for elder people/people with disabilities were particularly hit by the COVID-19 pandemic. Workers from these centres were included as a priority group for vaccination against SARS-CoV-2. The Family Ministry of Castilla y León realized a seroprevalence survey measuring the humoral immunity of its workers after the vaccination against SARS-CoV-2. ⋯ 99.8% of social health workers who received 2 doses of the BNT162b2 vaccine from Pfizer/BioNtech, and 94% of those who received 1 single dose, presented humoral immunity with high IgG titers, with high clinical effectiveness expressed in the absence of cases. 64% of unvaccinated workers presented humoral immunity. The history of having passed COVID-19 produces an important booster effect both after one and after two doses of vaccine. Measurement of humoral immunity against SARS-CoV-2 could be considered as a parameter for sufficient immunity.