COPD
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Randomized Controlled Trial
Severe chronic bronchitis in advanced emphysema increases mortality and hospitalizations.
Chronic bronchitis in COPD has been associated with an increased exacerbation rate, more hospitalizations, and an accelerated decline in lung function. The clinical characteristics of patients with advanced emphysema and chronic bronchitis have not been well described. ⋯ Severe chronic bronchitis is associated with worse survival, shorter time to hospitalization, and worse health-related quality of life.