Physiology & behavior
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Physiology & behavior · Aug 2012
The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats.
Rats that consume high-energy (HE) diets (i.e., diets high in saturated fats and sugar) show impaired hippocampal-dependent learning and memory (e.g., Kanoski and Davidson (2011) [1]). To further investigate this effect, we trained rats given restricted access to low-fat lab chow on hippocampal-dependent serial feature-negative (FN) and hippocampal-independent simple discrimination problems. When training was completed, Group Chow received ad libitum lab chow. ⋯ However, HE diet-induced obese (HE-DIO) rats (i.e., rats that weighed the most weight and had the most body fat) performed like Group Chow on the simple discrimination problem, but were impaired throughout testing on the FN problem. Subsequent assessment of blood-brain barrier (BBB) permeability revealed that concentrations of an exogenously administered dye were elevated in the hippocampus, but not in the striatum or prefrontal cortex for HE-DIO rats relative to the HE-DR and Chow groups. The results indicate that the adverse consequences of HE diet on hippocampal-dependent cognitive functioning are associated with detrimental effects on the BBB and that both of these outcomes vary with sensitivity to HE diet-induced increases in weight and adiposity.
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Physiology & behavior · Aug 2012
A sigh following sustained attention and mental stress: effects on respiratory variability.
Normal breathing consists of considerable correlated variability (parameters of subsequent breaths are correlated) and some random variability. Emotional and attentive states alter normal breathing variability, which can be restored by a sigh. The present study aimed to investigate the effects of mental arithmetic and sustained attention on respiratory variability. ⋯ A spontaneous sigh restored correlated variability. An instructed sigh restored correlated variability following mental arithmetic, and increased total variability following sustained attention. These results suggest that a spontaneous sigh and an instructed sigh, when physiologically appropriate, restore respiratory variability influenced by stress or attention.