Physiology & behavior
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To explore the role of strong negative emotions in spinal nociception, we evaluated the effect of fear-relevant videos of small animals on the nociceptive withdrawal reflex (NWR) and reflex-related pain perception in healthy subjects with a specific phobia of small animals. Twenty healthy subjects with a specific phobia of small animals diagnosed according to DSM-V criteria were included in this study. The NWR was evoked in the lower limb by stimulating the sural nerve and recording EMG activity in the biceps femoris. ⋯ Emotions induced by phobic video viewing increase the alertness devoted to the defensive reaction by emphasizing nociceptive responses independently from pain perception. The NWR may represent an interesting tool for exploring the interaction between strong negative emotions and spinal nociception. A better understanding of this mechanism may be a theoretical prerequisite for the optimization of pain management in several chronic pain syndromes.
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Physiology & behavior · Jul 2019
Access to voluntary running wheel exercise: Prevention of anxiety-like behavior in chronically stressed rats, but potentiation of ethanol intake/preference.
The current study tested the effect of voluntary running on future anxiety-like behavior, physiological response to stress, and ethanol intake/preference, while including a chronically stressed group and healthy group housed conspecifics. When given concurrently, voluntary running reduces ethanol intake, though it is unknown what effect voluntary running will have on anxiety-like behavior, corticosterone response to stress, and ethanol intake/preference when exercise is allowed only prior to ethanol access. Adolescent male Long Evans rats arrived in the lab at postnatal day (PND) 21. ⋯ In regard to ethanol intake and preference, running (irrespective of housing group) increased intake at the 30 min time point and preference at the 24 h time point. Altogether, these data show that access to voluntary exercise was successful in reducing anxiety-like behavior, but withdrawal of exercise access appeared to enhance ethanol intake/preference. We suggest that these data reflect hedonic substitution.