International journal of surgery
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Bacterial translocation occurs when intestinal mucosa and the intestinal wall lose their barrier properties against bacteria such as in the case of intestinal obstruction. Enteral nutrition with immunonutrients strengthens the immune system and thickens the intestinal barrier thus preventing bacterial translocation. ⋯ Uracil may be used in the prevention of bacterial translocation in cases of intestinal obstruction because it strengthens the intestinal barrier and the immune system. However, more studies are needed to clearly explain the mechanism behind uracil's beneficial role here.
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The objective was to assess the effect of locally administered curcumin on peripheral nerve regeneration and functional recovery. Thirty male healthy white Wistar rats were divided into two experimental groups (n = 15), randomly: In control group (CG), the left sciatic nerve was exposed and transected proximal to tibio-peroneal bifurcation leaving a 10-mm gap. Proximal and distal stumps were each inserted into a silicone tube and filled with 10 μL sterilized olive oil. ⋯ In immunohistochemistry, location of reactions to S-100 in TG was clearly more positive than that in CG group. When loaded in a silicone tube, curcumin improved functional recovery and morphometric indices of sciatic nerve. Curcumin is readily available and its local application is easily performed without limitations of its poor bioavailability in systemic administration.