Expert opinion on drug delivery
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Expert Opin Drug Deliv · Jan 2016
Highly respirable dry powder inhalable formulation of voriconazole with enhanced pulmonary bioavailability.
To develop and characterize a highly respirable dry powder inhalable formulation of voriconazole (VRZ). ⋯ This study supports the potential of inhaled dry powder VRZ for the treatment of fungal infections.
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Cardiovascular disease (CVD) is the leading cause of mortality globally. Effective CVD preventive medications are available including statin, blood pressure-lowering and antiplatelet medications; however most people do not take these drugs long term. Fixed-dose combination pills ("polypills") have been shown, in several clinical trials, to improve adherence to these recommended medications, with corresponding improvements in risk factors such as blood pressure and LDL-cholesterol. ⋯ Despite the potential benefits for patients and payers, only a few polypills are available due to market failure in the funding of research and development for affordable non-communicable disease medicines. Regulatory paradigms have focused on substitution indications among patients already taking component medications; however, this is the population that is likely to receive the least benefit from a polypill-based strategy. Greater health impact is likely if focus is given to patients who have indications for all polypill components, but currently do not receive the benefits of recommended medicines long term.