Expert review of medical devices
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Expert Rev Med Devices · May 2007
ReviewClinical experience with the iLA Membrane Ventilator pumpless extracorporeal lung-assist device.
Extracorporeal gas exchange by extracorporeal membrane oxygenation has been established clinically in patients with acute lung failure. The interventional lung-assist (iLA) Membrane Ventilator device (Novalung) is a sophisticated representative of a new generation of pumpless extracorporeal lung-assist devices that are driven by the patient's cardiac output and therefore, do not require extracorporeal pump assistance. ⋯ This particular pumpless extracorporeal lung-assist device was applied in 1800 patients for artificial lung assistance with easy use and low cost. This article reviews the present state of clinical Novalung device implementation focusing on encountered limitations and conceivable future developments in the field.
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Expert Rev Med Devices · May 2007
ReviewNegative pressure ventilation via diaphragmatic pacing: a potential gateway for treating systemic dysfunctions.
Programmed diaphragmatic pacing using implanted neuromodulators represents an emerging method for providing pulmonary support using negative pressure ventilation. The implantable, rechargeable, programmable and miniaturized nature of diaphragmatic pacers may obviate many of the management issues associated with noninvasive positive pressure ventilation devices. ⋯ In addition, it might alleviate subclinical hypoventilation--a condition that may affect a significant proportion of the aging population. Diaphragmatic pacing could also reduce sympathetic bias, which may contribute to a wide range of diseases associated with autonomic dysfunction.