Journal of electrocardiology
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Clinical Trial
QT interval and repolarization time in patients with intraventricular conduction delay.
A prolonged QT interval is an important prognostic indicator for cardiac arrhythmias and sudden death. The conventional QT interval measurement, however, includes in its measure the cardiac depolarization (QRS) as well as the cardiac repolarization (JT) intervals. To evaluate the relative contribution of the depolarization and the repolarization time prolongation to the prolonged QT interval in patients with intraventricular conduction delay (IVCD), the QRS, QT, and JT intervals were measured in 72 subjects with various types of IVCD. ⋯ All of these intervals were significantly prolonged compared to 430 +/- 4.3 msec in the control group. The prolongation of QTc interval in each category of IVCD subjects was entirely secondary to a prolonged depolarization time, as the repolarization intervals were not significantly different from those observed in the control group (F = 0.5, p = NS). These observations may provide an explanation for the differential prognosis for subjects with prolonged QT interval with prolonged repolarization time as compared to those with prolonged QT interval with prolonged depolarization time.
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Perioperative cardiac morbidity remains a significant problem in both cardiac and noncardiac surgical patients. The role of perioperative myocardial ischemia appears to be important and is under active investigation. In a series of studies in 200 high-risk patients undergoing noncardiac surgery or coronary artery bypass graft (CABG) surgery, we measured the pre-, intra-, and post-operative electrocardiographic (ECG) ischemic patterns using either continuous 2-lead ambulatory (Holter) monitoring or continuous 12-lead (modified treadmill) monitoring. ⋯ Most ECG ischemic episodes were supply-dependent, not demand-dependent. Comparing the pattern of intraoperative ischemia with the chronic ambulatory preoperative pattern, we found that, under conditions of strict hemodynamic control, intraoperative ischemia apparently recapitulated the preoperative pattern, and that the stresses of anesthesia and surgery contributed less than previously thought. The highest incidence of ischemia occurred postoperatively, ranging between 30% and 60%, in both cardiac and noncardiac surgical patients.(ABSTRACT TRUNCATED AT 250 WORDS)