PLoS medicine
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Randomized Controlled Trial
Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray.
In contrast to many animal model studies, immunotherapeutic trials in humans suffering from cancer invariably result in a broad range of outcomes, from long-lasting remissions to no discernable effect. ⋯ Such multiparametric analysis of T cell antigen specificity and function provides a valuable tool with which to dissect the molecular underpinnings of immune responsiveness and how this information correlates with clinical outcome.
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Dyer and colleagues examine the most promising preclinical models that recapitulate the molecular, genetic, and cellular features of retinoblastoma.