The Lancet. Microbe
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The Lancet. Microbe · Jan 2022
T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study.
Previous infection with SARS-CoV-2 affects the immune response to the first dose of the SARS-CoV-2 vaccine. We aimed to compare SARS-CoV-2-specific T-cell and antibody responses in health-care workers with and without previous SARS-CoV-2 infection following a single dose of the BNT162b2 (tozinameran; Pfizer-BioNTech) mRNA vaccine. ⋯ UK Department of Health and Social Care, and UK Coronavirus Immunology Consortium.
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The Lancet. Microbe · Oct 2021
Correction to Lancet Microbe 2020; published online July 6. https://doi.org/10.1016/S2666-5247(21)00146-4.
[This corrects the article DOI: 10.1016/S2666-5247(21)00146-4.].
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The Lancet. Microbe · Sep 2021
Comparative performance of SARS-CoV-2 lateral flow antigen tests and association with detection of infectious virus in clinical specimens: a single-centre laboratory evaluation study.
Lateral Flow Devices / RATs show good correlation with low cycle threshold PCR results, and subsequent viral culture, indicating excellent sensitivity for identifying contagious individuals.
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The Lancet. Microbe · Apr 2021
Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study.
SARS-CoV-2 rapid antigen test positivity correlates well with viral loads typically seen in the infectious period. RATs may be useful tools to discriminate between infectious and non-infectious individuals.
pearl -
The Lancet. Microbe · Jan 2021
SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis.
Viral load kinetics and duration of viral shedding are important determinants for disease transmission. We aimed to characterise viral load dynamics, duration of viral RNA shedding, and viable virus shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in various body fluids, and to compare SARS-CoV-2, SARS-CoV, and Middle East respiratory syndrome coronavirus (MERS-CoV) viral dynamics. ⋯ None.